Human Sera
Cayman Chemical DIhydroRgocrIstInmSylate 100mg
An alkaloid with diverse biological activities; inhibits contraction of isolated rat vas deferens induced by norepinephrine (pA2 = 7.88); reduces blood pressure in a rat model of norepinephrine-induced hypertension and increases blood pressure in hypotensive rats from 0.1-100 UG/kg, i.v.; reduces aqueous humor production and intraocular pressure in a rabbit model of α-chymotrypsin-induced ocular hypertension; reduces hypermotility induced by ethanol in mice
Cayman Chemical 3methoxy TyramInhydroCLO 100mg
A natural metabolite of dopamine; a weak agonist of TAAR1 (EC50 = 1.7 µM)
Cayman Chemical LoperamIdehydrochlorIde 50mg
An opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery; has antidiarrheal action; blocks voltage-sensitive sodium channels (IC50 = 270 nM) and high voltage-activated calcium channels (IC50 = 900 nM); comparable to morphine in blocking peripheral pain
Cayman Chemical Terbutaln 50mg
A β2-adrenergic receptor agonist; an active metabolite of bambuterol; binds to β1-, β2-, and β3-ARs (Ki = 31.3, 15.4, and 79.8 nM, respectively); selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β2- or β3- over β1-ARs at concentrations 100-fold greater than the respective Ki values; inhibits airway obstruction induced by methacholine or LTD4 in anesthetized guinea pigs
Cayman Chemical RosmarInIc AcId 100mg
Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 UG/ml.{4778} Rosmarinic acid suppresses endotoxin-induced activation of complement and concomitant formation of prostacyclin.{4407,4408} Formation of 5-HETE and LTB4 from human PMNL is inhibited by rosmarinic acid at concentrations of 10-5 to 10-3 M.{4706}
Cayman Chemical DrondaronhydrochlorIde 50mg
An antiarrhythmic agent; inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively); reduces sinus frequency and prolongs APD in isolated rabbit ventricular myocardium at 50 and 100 mg/kg; increases atrial APD and the AERP in a dog model of atrial fibrillation
Cayman Chemical IfenprodIlhemItartrate 50mg
A selective antagonist of NR1A/NR2B subunit-containing NMDA receptors (IC50 = 340 nM); selective for NR1A/NR2B subunit-containing NMDA receptors over those containing NR1A/NR2A or NR1A/NR2C subunits (IC50s = 20 and >100 µM, respectively); binds to σ1 receptors, emopamil binding protein, and fungal C-8 sterol isomerase/ERG2 (Kis = 2, 5, and 1 nM, respectively), as well as α1-ARs (IC50 = 110 nM), 5-HT1A and 5-HT2 (IC50s = 238 and 610 µM, respectively); inhibits infection of MDCK cells by H1N1 and H3N2 influenza isolates in vitro (EC50s = 6.6 and 16.9 µM, respectively); increases NGF, BDNF, and GDNF production in primary mouse astrocytes at 150 µM; reduces maximal electroshock seizures in mice (ED50s = 16 and 7 mg/kg, respectively)
Cayman Chemical DetomIdInhydrochlorIde 100mg
A selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM); primarily used as a sedative for horses in large animal veterinary medicine
Cayman Chemical N- p-amylcInamoyl nthrnIl 50mg
A channel blocker that acts on several TRP channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively); inhibits PLA2, blocking the release of arachidonic acid when given at 50 μM
Cayman Chemical N-OxalylglycIn 50mg
A cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC50s = 250, 500, and 24 μM, respectively); inhibits the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC50 values of 2.1 and 5.6 μM, respectively
Cayman Chemical 5a-ndrost-16-en-3a-ol 50mg
A pheromone with diverse biological activities; enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 = 0.4 µM); increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2 and α2β2γ2 subunit-containing GABAA receptors from 0.1-1 µM; has antidepressant-like effects in mice from 5-10 mg/kg; has anxiolytic-like effects in mice from 30-50 mg/kg; protects against PTZ- or electroshock-induced seizures in mice (ED50s = 48.9 and 21.9 mg/kg, respectively)
Revvity Health Sciences Inc CytoStar-T 96-well plate, 100 plates
CytoStar-T 96-well plate, 100 plates
Cayman Chemical Boldenon CypIonate 50mg
An ester of boldenone, an anabolic androgenic steroid; intended for forensic and research purposes only