Human Sera
Cayman Chemical TrIfluorothymIdIn 100mg
A muscarinic receptor agonist (EC50s 23 48 and 63 nM for M1 M3 and M5 respectively and 1 UM for M2 and M4) stimulates secretion by salivary glands and is useful in ameliorating xerostomia (dry mouth)
Cayman Chemical NIlvadIpIn 100mg
A JAK1 and JAK2 inhibitor (IC50s 0 0059 and 0 0057 UM respectively) selective for JAK1 and JAK2 over JAK3 TYK2 c-Met and Chk2 (IC50s 0 4 0 053 10 and 1 UM respectively) inhibits IL-6-induced phosphorylation of STAT3 in isolated human PBMCs and rat whole blood (IC50s 0 044 and 0 128 UM respectively) reduces disease severity in a type II collagen-induced mouse model of arthritis at 3 and 10 mg/kg decreases lung macrophage infiltration and disease severity in rhesus monkeys infected with SARS-CoV-2 at 4 mg/animal
Cayman Chemical TrospIumchlorIde 100mg
A cell-permeable asymmetrical indolocarbazole that exhibits antiproliferative activity by selectively blocking cyclin D1/Cdk4 (IC50 0 8 M) inhibits HCT116 and NCI-H460 tumor cell growth (IC50s 1 cell cycle arrest
Cayman Chemical TopIroxostat 100mg
A synthetic derivative of native coelenterazine that exhibits 16-fold higher luminescence intensity (emission maximum 466 nm half-total time of 0 6-1 2 sec) than native coelenterazine
Cayman Chemical GrazoprevIr 50mg
LRH-1 Reporter Cells are prepared using INDIGOs proprietary CryoMite process This cryo-preservation method yields high cell viability post-thaw and provides the convenience of immediately dispensing healthy division-competent reporter cells into assay plates There is no need for intermediate spin-and-wash steps viability determinations or cell titer adjustments [INDIGO Catalog Nos IB11001-32 IB11001 IB11002]
Cayman Chemical HenIcosnoIc AcId 100mg
An EED protein-protein interaction inhibitor binds to the EED subunit of PRC2 and inhibits H3K27 methylation (Ki 0 4 nM) inhibits H3K27 di- and trimethylation in RD rhabdoid tumor cells (IC50s 390 and 90 nM respectively) reduces tumor volume and intratumor H3K27 trimethylation in a Pfeiffer DLBCL mouse xenograft model at 200 mg/kg
Cayman Chemical MelperonhydrochlorIde 50mg
A specific adenosine A2 receptor agonist with antipyretic and anticonvulsant activity stimulates the production of cyclic AMP in CHO-K1 cells with an EC50 value of 5 3 UM
Cayman Chemical VelpatsvIr 100mg
A JAK1 and JAK2 inhibitor (IC50s 0 0059 and 0 0057 UM respectively) selective for JAK1 and JAK2 over JAK3 TYK2 c-Met and Chk2 (IC50s 0 4 0 053 10 and 1 UM respectively) inhibits IL-6-induced phosphorylation of STAT3 in isolated human PBMCs and rat whole blood (IC50s 0 044 and 0 128 UM respectively) reduces disease severity in a type II collagen-induced mouse model of arthritis at 3 and 10 mg/kg decreases lung macrophage infiltration and disease severity in rhesus monkeys infected with SARS-CoV-2 at 4 mg/animal
Cayman Chemical DIpIvefrInhydrochlorIde 100mg
A GAD inhibitor reduces GAD activity by 60 when administered at a dose of 39.8 mol/g per hour ex vivo in mouse brain preparations i.p. administration (1.2 mmol/kg) induces convulsions and decreases GABA concentration throughout the cerebellum pons medulla striatum cortex and hippocampus in mice chronic administration (3.2 g/0.5 l per hour for 13 days) increases locomotor activity in an open field test and impairs attention in the 5-choice serial reaction time task (5CSRTT) inhibits GAD in vitro only when used at high concentrations (1-80 mM)
Cayman Chemical PhosphatIdylcholInchIcken 50mg
An L- and T-type calcium channel blocker blocks recombinant rabbit L-type (a1Ca2/B1a) and human T-type (a1H) calcium channels expressed in Xenopus oocytes blocks native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 2.6 nM) inhibits ET-1-induced increases in intracellular calcium in A7r5 rat vascular smooth muscle cells (ED50 1 nM) inhibits potassium-induced contraction of isolated dog femoral and portal veins (IC50s 24 and 2.1 nM respectively) lowers blood pressure in SHRs (10 mg/kg) inhibits isoproterenol-induced left ventricular hypertrophy in rats (3 mg/kg)
Cayman Chemical 6-OHDAhydrobromIde 50mg
An amphetamine whose physiological and toxicological properties are not known
Cayman Chemical mperatrn 50mg
A non-selective protein kinase inhibitor (IC50s 20 36 7 and 420 M for PKC A G and M respectively) has been widely used to characterize the functional roles of PKC in a multitude of cellular processes
Cayman Chemical ThIacloprId 50mg
A sulfonamide antibiotic inhibits DHPS inhibits growth of non-resistant P. falciparum
Cayman Chemical PhosphatIdylglyceroleggs 50mg
A membrane-permeable blocker of IKCa1/KCa3.1 (Kds 20 and 25 nM for the cloned and native channel in COS-7 cells and human T lymphocytes respectively) 200- to 1500-fold selective for IKCa1 over Kv (Kv1.1-Kv1.5 Kv3.1 Kv4.2) Kir2.1 BK/KCa1.1 SKCa (rSKCa2 hSKCa2 hSKCa3) native SKCa/KCa2 and CRAC in Jurkat T cells as well as sodium and chloride channels suppresses reactivation of human-derived T lymphocytes stimulated with anti-CD3 antibody (mean EC50s 295 and 910 nM from sensitive and less sensitive human donors respectively) inhibits proliferation of human endometrial cancer cells and induces cell cycle arrest at the G0/G1 phase inhibits proliferation of LNCaP and PC3 prostate cancer cells inhibits proliferation induced by epidermal growth factor (EGF) in smooth muscle A7r5 cells (IC50 8 nM) reduces intimal hyperplasia by approximately 40 after 1 2 and 6 weeks in a rat model of balloon catheter injury when administered at a dose of 120 mg/kg per day pretreatment
